Level of Human TCRBV 3 S 1 ( V 33 ) Expression Correlates with Allelic Polymorphism in the Spacer Region of the Recombination Signal Sequence
نویسندگان
چکیده
From the "Department of Medicine, Cornelt University Medical College and the ~Immunotogy Program, Cornell University Graduate School of Medical Sciences, New York 10021; the SVirginia Mason Research Center, Seattle, Washington 98101; the IIDepartment of Immunology, University of Washington School of Medicine, Seattle, Washington 98195; the %aboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852; and the "*Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710
منابع مشابه
Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence
One of the causes of variations in the expressed human T cell receptor (TCR) BV (V beta) repertoire is genetic variation in the germline DNA. Herein evidence is provided that allelic polymorphism may affect recombination frequency for a specific V gene. Two alleles of the TCR BV3 differ only at a single nucleotide position (C/T) within the 23-bp spacer region of the recombination signal sequenc...
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